The expedition departs from Camp Wood, Missouri, traveling in a keelboat and two smaller boats. To read excerpts of Lewis and Clark's journals, click on "Setting Forth."
The first official meeting takes place between the expedition and a group of Oto Native Americans in the territory that is now Nebraska.
Sergeant Charles Floyd dies of a burst appendix near Sioux City, Iowa.
The expedition unsuccessfully attempts to capture a prairie dog by pouring water down its hole.
Fighting almost breaks out when a group of Teton Sioux Native Americans demands one of the expedition's boats as payment for traveling upriver. Chief Black Buffalo helps resolve the argument.
They reach the Mandan Villages in North Dakota and are welcomed by the Mandan Native Americans. They decide to build their winter camp there and name it "Fort Mandan."
Charbonneau and Sacagawea join the expedition as interpreters and guides. Sacagawea became one of the most famous members of the Corps.
Lewis and fifteen men join in their first buffalo hunt.
Continue to see the trail today.