All times are Eastern Time
April 7The league kicks off with five games. The featured match is D.C. United at the Colorado Rapids at the Rapids' new stadium, Dick's Sporting Goods Park in Commerce, Colo., on ABC at 3:30 p.m.
April 7Toronto FC, the first non-U.S. based MLS club, will play its first game against Chivas USA at The Home Depot Center in Carson, Calif. at 10:30 p.m.
April 8The defending champion Houston Dynamo hosts the Los Angeles Galaxy at 4 p.m.
April 28The first MLS game not to be played in the United States and the league's first game in Canada will take place in Toronto when Toronto FC hosts the Kansas City Wizards at 20,000 seat BMO Field at Exhibition Place at 12:30 p.m. that Saturday.
April 28In the first of four meetings between these two rivals who share the same stadium in Carson, Calif.the Galaxy hosts Chivas USA at 10:30 p.m. The other key confrontations: May 20 (Chivas is the home team), Aug. 23 (L.A.) and Sept. 13 (Sept. 13).
July 19In a rare weekend all-star game, the league's brightest stars will come out with the 12th annual MLS all-star game vs. perennial Scottish power Celtic FC at Dick's Sporting Goods Park, 9 p.m.
July 21With Beckhamania expected to sweep through the league this summer, at the moment there are three key dates in his debut. David Beckham could make his first appearance in a Galaxy uniform against English Premiership champions Chelsea in an exhibition game at The Home Depot Center that Saturday (time to be determined).
July 24/27Beckham could play in his first competitive match for L.A. in the SuperLiga against either C.D. Guadalajara (Mexico) on Tuesday, July 24 or vs. Pachuca (Mexico) Saturday, July 28 (the SuperLiga is a competition between U.S. and Mexican teams).
Aug. 5Beckham's MLS debut is expected to be at the expansion Toronto FC that Sunday at 7 p.m.
Aug. 9The first time Beckham plays in the U.S. on American soil will be vs. D.C. United at 7 p.m. that Thursday.
Oct. 21The Chicago Fire meets the Galaxy in the league's final regular-season matchup at 3 p.m.
Oct. 24MLS playoffs begin. The top two teams in each conference qualify with the next four teams with the most points, regardless of what conference in which they play.
Nov. 18MLS Cup at RFK Stadium, Washington, D.C. at noon that Sunday. This is the third time the stadium will play host to the championship, including 1997 and 2000.