System 44 was designed to be used daily (55–60 minutes) with a small class (10–12 students). Students spend a minimum of 20 minutes on the Software alternating between small-group differentiation and modeled/independent reading. The program can be used effectively during a regular class period, in a resource room, and in after- and summer-school programs.

System 44 was also designed to work seamlessly with READ 180 in an integrated classroom. Based on data from the Scholastic Reading Inventory (SRI) and the Scholastic Phonics Inventory (SPI), students in need of foundational skills should be identified and grouped together to form a group (or two groups) that travel through rotations together.